Publication

Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps

Authors: Chen B, Scurrah CR, McKinley ET, Simmons AJ, Ramirez-Solano MA, Zhu X, Markham NO, Heiser CN, Vega PN, Rolong A, Kim H, Sheng Q, Drewes JL, Zhou Y, Southard-Smith AN, Xu Y, Ro J, Jones AL, Revetta F, Berry LD, Niitsu H, Islam M, Pelka K, Hofree M, Chen JH, Sarkizova S, Ng K, Giannakis M, Boland GM, Aguirre AJ, Anderson AC, Rozenblatt-Rosen O, Regev A, Hacohen N, Kawasaki K, Sato T, Goettel JA, Grady WM, Zheng W, Washington MK, Cai Q, Sears CL, Goldenring JR, Franklin JL, Su T, Huh WJ, Vandekar S, Roland JT, Liu Q, Coffey RJ, Shrubsole MJ, Lau KS
Journal: Cell  Pubmed: 34910928   DOI: 10.1016/j.cell.2021.11.031
Atlas: Vanderbilt University

Abstract

Colorectal cancers (CRCs) arise from precursor polyps whose cellular origins, molecular heterogeneity, and immunogenic potential may reveal diagnostic and therapeutic insights when analyzed at high resolution. We present a single-cell transcriptomic and imaging atlas of the two most common human colorectal polyps, conventional adenomas and serrated polyps, and their resulting CRC counterparts. Integrative analysis of 128 datasets from 62 participants reveals adenomas arise from WNT-driven expansion of stem cells, while serrated polyps derive from differentiated cells through gastric metaplasia. Metaplasia-associated damage is coupled to a cytotoxic immune microenvironment preceding hypermutation, driven partly by antigen-presentation differences associated with tumor cell-differentiation status. Microsatellite unstable CRCs contain distinct non-metaplastic regions where tumor cells acquire stem cell properties and cytotoxic immune cells are depleted. Our multi-omic atlas provides insights into malignant progression of colorectal polyps and their microenvironment, serving as a framework for precision surveillance and prevention of CRC.


Data Availability
FilesCRDC-GC/SB-CGC (dbGaP )CRDC-GC/SB-CGC (Open Access )Synapse (Open Access )Coming Soon
10X Visium Auxiliary0020
10X Visium Level 14000
10X Visium Level 22000
10X Visium Level 30080
10X Visium Level 40020
Bulk DNA Level 130006
Bulk DNA Level 215003
Bulk DNA Level 300180
H&E Level 202500
MxIF Level 207700
scRNA-seq Level 1154000
scRNA-seq Level 277000
scRNA-seq Level 300770
scRNA-seq Level 40040
Level
Columns (11/25)
Filename
Atlas Name
Publications
Biospecimen
Assay
Level
Organ
Diagnosis
Data Access
Metadata
View
HTAN Vanderbilt
HTA11_347_2000001011
scRNA-seq
Level 3
Not Reported
Not Reported
Synapse
HTAN Vanderbilt
HTA11_78_2000001011
scRNA-seq
Level 3
Not Reported
Not Reported
Synapse
HTAN Vanderbilt
HTA11_696_2000002011
scRNA-seq
Level 3
Not Reported
Not Reported
Synapse
HTAN Vanderbilt
HTA11_696_2000002021
scRNA-seq
Level 3
Not Reported
Not Reported
Synapse
HTAN Vanderbilt
HTA11_83_2000001011
scRNA-seq
Level 3
Not Reported
Not Reported
Synapse
HTAN Vanderbilt
HTA11_83_2000002021
scRNA-seq
Level 3
Not Reported
Not Reported
Synapse
HTAN Vanderbilt
HTA11_78_2000001011
scRNA-seq
Level 3
Not Reported
Not Reported
Synapse
HTAN Vanderbilt
HTA11_78_2000002011
scRNA-seq
Level 3
Not Reported
Not Reported
Synapse
HTAN Vanderbilt
HTA11_347_2000001011
scRNA-seq
Level 3
Not Reported
Not Reported
Synapse
HTAN Vanderbilt
HTA11_104_2000001011
scRNA-seq
Level 3
Not Reported
Not Reported
Synapse
HTAN Vanderbilt
HTA11_104_2000002021
scRNA-seq
Level 3
Not Reported
Not Reported
Synapse
HTAN Vanderbilt
HTA11_104_2000002011
scRNA-seq
Level 3
Not Reported
Not Reported
Synapse
HTAN Vanderbilt
HTA11_411_2000001011
scRNA-seq
Level 3
Not Reported
Not Reported
Synapse
HTAN Vanderbilt
HTA11_411_2000002011
scRNA-seq
Level 3
Not Reported
Not Reported
Synapse
HTAN Vanderbilt
HTA11_411_2000002021
scRNA-seq
Level 3
Not Reported
Not Reported
Synapse
HTAN Vanderbilt
HTA11_377_2000001011
scRNA-seq
Level 3
Not Reported
Not Reported
Synapse
HTAN Vanderbilt
HTA11_392_3000011011
scRNA-seq
Level 3
Not Reported
Not Reported
Synapse
HTAN Vanderbilt
HTA11_696_2000001011
scRNA-seq
Level 3
Not Reported
Not Reported
Synapse
HTAN Vanderbilt
HTA11_696_2000002011
scRNA-seq
Level 3
Not Reported
Not Reported
Synapse
HTAN Vanderbilt
HTA11_696_2000002021
scRNA-seq
Level 3
Not Reported
Not Reported
Synapse
HTAN Vanderbilt
HTA11_866_2000001011
scRNA-seq
Level 3
Not Reported
Not Reported
Synapse
HTAN Vanderbilt
HTA11_392_3000012011
scRNA-seq
Level 3
Not Reported
Not Reported
Synapse
HTAN Vanderbilt
HTA11_1391_2000001011
scRNA-seq
Level 3
Not Reported
Not Reported
Synapse
HTAN Vanderbilt
HTA11_546_2000001011
scRNA-seq
Level 3
Not Reported
Not Reported
Synapse
HTAN Vanderbilt
HTA11_546_2000002011
scRNA-seq
Level 3
Not Reported
Not Reported
Synapse
HTAN Vanderbilt
HTA11_546_2000002021
scRNA-seq
Level 3
Not Reported
Not Reported
Synapse
HTAN Vanderbilt
HTA11_2487_2000001011
scRNA-seq
Level 3
Not Reported
Not Reported
Synapse
HTAN Vanderbilt
HTA11_2487_2000002011
scRNA-seq
Level 3
Not Reported
Not Reported
Synapse
HTAN Vanderbilt
HTA11_2487_2000001011
scRNA-seq
Level 3
Not Reported
Not Reported
Synapse
HTAN Vanderbilt
HTA11_2992_2000001011
scRNA-seq
Level 3
Not Reported
Not Reported
Synapse
HTAN Vanderbilt
HTA11_2487_2000001011
scRNA-seq
Level 3
Not Reported
Not Reported
Synapse
HTAN Vanderbilt
HTA11_5363_2000002021
scRNA-seq
Level 3
Not Reported
Not Reported
Synapse
HTAN Vanderbilt
HTA11_5212_2000001011
scRNA-seq
Level 3
Not Reported
Not Reported
Synapse
HTAN Vanderbilt
HTA11_5212_2000002011
scRNA-seq
Level 3
Not Reported
Not Reported
Synapse
HTAN Vanderbilt
HTA11_5216_2000001011
scRNA-seq
Level 3
Not Reported
Not Reported
Synapse
HTAN Vanderbilt
2 Biospecimens
scRNA-seq
Level 3
Not Reported
Not Reported
Synapse
HTAN Vanderbilt
HTA11_5216_2000002021
scRNA-seq
Level 3
Not Reported
Not Reported
Synapse
HTAN Vanderbilt
HTA11_3252_2000002011
scRNA-seq
Level 3
Not Reported
Not Reported
Synapse
HTAN Vanderbilt
HTA11_3252_2000002021
scRNA-seq
Level 3
Not Reported
Not Reported
Synapse
HTAN Vanderbilt
HTA11_2487_2000001011
scRNA-seq
Level 3
Not Reported
Not Reported
Synapse
HTAN Vanderbilt
HTA11_3361_2000001011
scRNA-seq
Level 3
Not Reported
Not Reported
Synapse
HTAN Vanderbilt
HTA11_3361_2000001011
scRNA-seq
Level 3
Not Reported
Not Reported
Synapse
HTAN Vanderbilt
HTA11_3361_2000001011
scRNA-seq
Level 3
Not Reported
Not Reported
Synapse
HTAN Vanderbilt
HTA11_3361_2000002011
scRNA-seq
Level 3
Not Reported
Not Reported
Synapse
HTAN Vanderbilt
HTA11_3361_2000002021
scRNA-seq
Level 3
Not Reported
Not Reported
Synapse
HTAN Vanderbilt
HTA11_2112_2000001011
scRNA-seq
Level 3
Not Reported
Not Reported
Synapse
HTAN Vanderbilt
HTA11_2112_2000002021
scRNA-seq
Level 3
Not Reported
Not Reported
Synapse
HTAN Vanderbilt
HTA11_1938_2000001011
scRNA-seq
Level 3
Not Reported
Not Reported
Synapse
HTAN Vanderbilt
HTA11_1938_2000002011
scRNA-seq
Level 3
Not Reported
Not Reported
Synapse
HTAN Vanderbilt
HTA11_3331_2000001011
scRNA-seq
Level 3
Not Reported
Not Reported
Synapse
Level
Columns (11/25)
Filename
Atlas Name
Publications
Biospecimen
Assay
Level
Organ
Diagnosis
Data Access
Metadata
View
HTA11_83_2...09999.tif
HTAN Vanderbilt
HTA11_83_2000001011
H&E
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_347_...09999.tif
HTAN Vanderbilt
HTA11_347_2000001011
H&E
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_377_...09999.tif
HTAN Vanderbilt
HTA11_377_2000001011
H&E
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_392_...09999.tif
HTAN Vanderbilt
HTA11_392_3000011011
H&E
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_411_...09999.tif
HTAN Vanderbilt
HTA11_411_2000001011
H&E
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_546_...09999.tif
HTAN Vanderbilt
HTA11_546_2000001011
H&E
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_696_...09999.tif
HTAN Vanderbilt
HTA11_696_2000001011
H&E
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_866_...09999.tif
HTAN Vanderbilt
HTA11_866_2000001011
H&E
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_1391...09999.tif
HTAN Vanderbilt
HTA11_1391_2000001011
H&E
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_1938...09999.tif
HTAN Vanderbilt
HTA11_1938_2000001011
H&E
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_2112...09999.tif
HTAN Vanderbilt
HTA11_2112_2000001011
H&E
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_2235...09999.tif
HTAN Vanderbilt
HTA11_2235_2000001011
H&E
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_2487...09999.tif
HTAN Vanderbilt
HTA11_2487_2000001011
H&E
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_2951...09999.tif
HTAN Vanderbilt
HTA11_2951_2000001011
H&E
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_3331...09999.tif
HTAN Vanderbilt
HTA11_3331_2000001011
H&E
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_3361...09999.tif
HTAN Vanderbilt
HTA11_3361_2000001011
H&E
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_3410...09999.tif
HTAN Vanderbilt
HTA11_3410_2000001011
H&E
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_5212...09999.tif
HTAN Vanderbilt
HTA11_5212_2000001011
H&E
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_5216...09999.tif
HTAN Vanderbilt
HTA11_5216_2000001011
H&E
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_5363...09999.tif
HTAN Vanderbilt
HTA11_5363_2000001011
H&E
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_5994...09999.tif
HTAN Vanderbilt
HTA11_5994_2000001011
H&E
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_6025...09999.tif
HTAN Vanderbilt
HTA11_6025_2000001011
H&E
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_6134...09999.tif
HTAN Vanderbilt
HTA11_6134_2000001011
H&E
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_6147...09999.tif
HTAN Vanderbilt
HTA11_6147_2000001011
H&E
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_6310...09999.tif
HTAN Vanderbilt
HTA11_6310_2000001011
H&E
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

Level
Columns (11/25)
Filename
Atlas Name
Publications
Biospecimen
Assay
Level
Organ
Diagnosis
Data Access
Metadata
View
HTA11_1391...00000.tif
HTAN Vanderbilt
HTA11_1391_2000001011
MxIF
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_1391...00000.tif
HTAN Vanderbilt
HTA11_1391_2000001011
MxIF
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_1391...00000.tif
HTAN Vanderbilt
HTA11_1391_2000001011
MxIF
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_1938...00000.tif
HTAN Vanderbilt
HTA11_1938_2000001011
MxIF
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_1938...00000.tif
HTAN Vanderbilt
HTA11_1938_2000001011
MxIF
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_2112...00000.tif
HTAN Vanderbilt
HTA11_2112_2000001011
MxIF
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_2112...00000.tif
HTAN Vanderbilt
HTA11_2112_2000001011
MxIF
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_2112...00000.tif
HTAN Vanderbilt
HTA11_2112_2000001011
MxIF
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_2112...00000.tif
HTAN Vanderbilt
HTA11_2112_2000001011
MxIF
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_2235...00000.tif
HTAN Vanderbilt
HTA11_2235_2000001011
MxIF
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_2235...00000.tif
HTAN Vanderbilt
HTA11_2235_2000001011
MxIF
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_2235...00000.tif
HTAN Vanderbilt
HTA11_2235_2000001011
MxIF
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_2487...00000.tif
HTAN Vanderbilt
HTA11_2487_2000001011
MxIF
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_2487...00000.tif
HTAN Vanderbilt
HTA11_2487_2000001011
MxIF
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_2951...00000.tif
HTAN Vanderbilt
HTA11_2951_2000001011
MxIF
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_2951...00000.tif
HTAN Vanderbilt
HTA11_2951_2000001011
MxIF
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_2951...00000.tif
HTAN Vanderbilt
HTA11_2951_2000001011
MxIF
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_3331...00000.tif
HTAN Vanderbilt
HTA11_3331_2000001011
MxIF
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_3361...00000.tif
HTAN Vanderbilt
HTA11_3361_2000001011
MxIF
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_3361...00000.tif
HTAN Vanderbilt
HTA11_3361_2000001011
MxIF
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_3361...00000.tif
HTAN Vanderbilt
HTA11_3361_2000001011
MxIF
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_3361...00000.tif
HTAN Vanderbilt
HTA11_3361_2000001011
MxIF
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_3361...00000.tif
HTAN Vanderbilt
HTA11_3361_2000001011
MxIF
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_3361...00000.tif
HTAN Vanderbilt
HTA11_3361_2000001011
MxIF
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_3361...00000.tif
HTAN Vanderbilt
HTA11_3361_2000001011
MxIF
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_3361...00000.tif
HTAN Vanderbilt
HTA11_3361_2000001011
MxIF
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_3361...00000.tif
HTAN Vanderbilt
HTA11_3361_2000001011
MxIF
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_3361...00000.tif
HTAN Vanderbilt
HTA11_3361_2000001011
MxIF
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_3410...00000.tif
HTAN Vanderbilt
HTA11_3410_2000001011
MxIF
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_3410...00000.tif
HTAN Vanderbilt
HTA11_3410_2000001011
MxIF
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_3410...00000.tif
HTAN Vanderbilt
HTA11_3410_2000001011
MxIF
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_3410...00000.tif
HTAN Vanderbilt
HTA11_3410_2000001011
MxIF
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_3410...00000.tif
HTAN Vanderbilt
HTA11_3410_2000001011
MxIF
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_347_...00000.tif
HTAN Vanderbilt
HTA11_347_2000001011
MxIF
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_347_...00000.tif
HTAN Vanderbilt
HTA11_347_2000001011
MxIF
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_347_...00000.tif
HTAN Vanderbilt
HTA11_347_2000001011
MxIF
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_377_...00000.tif
HTAN Vanderbilt
HTA11_377_2000001011
MxIF
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_377_...00000.tif
HTAN Vanderbilt
HTA11_377_2000001011
MxIF
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_377_...00000.tif
HTAN Vanderbilt
HTA11_377_2000001011
MxIF
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_392_...00000.tif
HTAN Vanderbilt
HTA11_392_3000011011
MxIF
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_392_...00000.tif
HTAN Vanderbilt
HTA11_392_3000011011
MxIF
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_392_...00000.tif
HTAN Vanderbilt
HTA11_392_3000011011
MxIF
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_392_...00000.tif
HTAN Vanderbilt
HTA11_392_3000011011
MxIF
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_392_...00000.tif
HTAN Vanderbilt
HTA11_392_3000011011
MxIF
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_392_...00000.tif
HTAN Vanderbilt
HTA11_392_3000011011
MxIF
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_411_...00000.tif
HTAN Vanderbilt
HTA11_411_2000001011
MxIF
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)
Image Viewer Coming Soon
HTA11_411_...00000.tif
HTAN Vanderbilt
HTA11_411_2000001011
MxIF
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_411_...00000.tif
HTAN Vanderbilt
HTA11_411_2000001011
MxIF
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_411_...00000.tif
HTAN Vanderbilt
HTA11_411_2000001011
MxIF
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

HTA11_5212...00000.tif
HTAN Vanderbilt
HTA11_5212_2000001011
MxIF
Level 2
Not Reported
Not Reported
CRDC-GC/SB-CGC (open access)

Level
Columns (11/25)
Filename
Atlas Name
Publications
Biospecimen
Assay
Level
Organ
Diagnosis
Data Access
Metadata
View
6109-AS-1_...fastq.gz
HTAN Vanderbilt
HTA11_696_2000001011
Bulk DNA
Level 1
Not Reported
Not Reported
dbGaP
6109-AS-1_...fastq.gz
HTAN Vanderbilt
HTA11_696_2000001011
Bulk DNA
Level 1
Not Reported
Not Reported
dbGaP
6109-AS-10...fastq.gz
HTAN Vanderbilt
HTA11_5363_2000001011
Bulk DNA
Level 1
Not Reported
Not Reported
dbGaP
6109-AS-10...fastq.gz
HTAN Vanderbilt
HTA11_5363_2000001011
Bulk DNA
Level 1
Not Reported
Not Reported
dbGaP
6109-AS-11...fastq.gz
HTAN Vanderbilt
HTA11_6025_2000001011
Bulk DNA
Level 1
Not Reported
Not Reported
dbGaP
6109-AS-11...fastq.gz
HTAN Vanderbilt
HTA11_6025_2000001011
Bulk DNA
Level 1
Not Reported
Not Reported
dbGaP
6109-AS-12...fastq.gz
HTAN Vanderbilt
HTA11_6134_2000001011
Bulk DNA
Level 1
Not Reported
Not Reported
dbGaP
6109-AS-12...fastq.gz
HTAN Vanderbilt
HTA11_6134_2000001011
Bulk DNA
Level 1
Not Reported
Not Reported
dbGaP
6109-AS-13...fastq.gz
HTAN Vanderbilt
HTA11_6310_2000001011
Bulk DNA
Level 1
Not Reported
Not Reported
dbGaP
6109-AS-13...fastq.gz
HTAN Vanderbilt
HTA11_6310_2000001011
Bulk DNA
Level 1
Not Reported
Not Reported
dbGaP
6109-AS-14...fastq.gz
HTAN Vanderbilt
HTA11_6147_2000001011
Bulk DNA
Level 1
Not Reported
Not Reported
dbGaP
6109-AS-14...fastq.gz
HTAN Vanderbilt
HTA11_6147_2000001011
Bulk DNA
Level 1
Not Reported
Not Reported
dbGaP
6109-AS-2_...fastq.gz
HTAN Vanderbilt
HTA11_1391_2000001011
Bulk DNA
Level 1
Not Reported
Not Reported
dbGaP
6109-AS-2_...fastq.gz
HTAN Vanderbilt
HTA11_1391_2000001011
Bulk DNA
Level 1
Not Reported
Not Reported
dbGaP
6109-AS-3_...fastq.gz
HTAN Vanderbilt
HTA11_3331_2000001011
Bulk DNA
Level 1
Not Reported
Not Reported
dbGaP
6109-AS-3_...fastq.gz
HTAN Vanderbilt
HTA11_3331_2000001011
Bulk DNA
Level 1
Not Reported
Not Reported
dbGaP
6109-AS-4_...fastq.gz
HTAN Vanderbilt
HTA11_2235_2000001011
Bulk DNA
Level 1
Not Reported
Not Reported
dbGaP
6109-AS-4_...fastq.gz
HTAN Vanderbilt
HTA11_2235_2000001011
Bulk DNA
Level 1
Not Reported
Not Reported
dbGaP
6109-AS-8_...fastq.gz
HTAN Vanderbilt
HTA11_5212_2000001011
Bulk DNA
Level 1
Not Reported
Not Reported
dbGaP
6109-AS-8_...fastq.gz
HTAN Vanderbilt
HTA11_5212_2000001011
Bulk DNA
Level 1
Not Reported
Not Reported
dbGaP
6109-AS-9_...fastq.gz
HTAN Vanderbilt
HTA11_5216_2000001011
Bulk DNA
Level 1
Not Reported
Not Reported
dbGaP
6109-AS-9_...fastq.gz
HTAN Vanderbilt
HTA11_5216_2000001011
Bulk DNA
Level 1
Not Reported
Not Reported
dbGaP
5234-AS-67...fastq.gz
HTAN Vanderbilt
HTA11_1938_2000001011
Bulk DNA
Level 1
Not Reported
Not Reported
dbGaP
5234-AS-67...fastq.gz
HTAN Vanderbilt
HTA11_1938_2000001011
Bulk DNA
Level 1
Not Reported
Not Reported
dbGaP
5234-AS-68...fastq.gz
HTAN Vanderbilt
HTA11_866_2000001011
Bulk DNA
Level 1
Not Reported
Not Reported
dbGaP
5234-AS-68...fastq.gz
HTAN Vanderbilt
HTA11_866_2000001011
Bulk DNA
Level 1
Not Reported
Not Reported
dbGaP
5234-AS-69...fastq.gz
HTAN Vanderbilt
HTA11_347_2000001011
Bulk DNA
Level 1
Not Reported
Not Reported
dbGaP
5234-AS-69...fastq.gz
HTAN Vanderbilt
HTA11_347_2000001011
Bulk DNA
Level 1
Not Reported
Not Reported
dbGaP
5234-AS-70...fastq.gz
HTAN Vanderbilt
HTA11_2487_2000001011
Bulk DNA
Level 1
Not Reported
Not Reported
dbGaP
5234-AS-70...fastq.gz
HTAN Vanderbilt
HTA11_2487_2000001011
Bulk DNA
Level 1
Not Reported
Not Reported
dbGaP
MAP.01938_...recal.bam
HTAN Vanderbilt
HTA11_1938_2000001011
Bulk DNA
Level 2
Not Reported
Not Reported
dbGaP
MAP.00866_...recal.bam
HTAN Vanderbilt
HTA11_866_2000001011
Bulk DNA
Level 2
Not Reported
Not Reported
dbGaP
MAP.00347_...recal.bam
HTAN Vanderbilt
HTA11_347_2000001011
Bulk DNA
Level 2
Not Reported
Not Reported
dbGaP
MAP.02487_...recal.bam
HTAN Vanderbilt
HTA11_2487_2000001011
Bulk DNA
Level 2
Not Reported
Not Reported
dbGaP
MAP.00696_...recal.bam
HTAN Vanderbilt
HTA11_696_2000001011
Bulk DNA
Level 2
Not Reported
Not Reported
dbGaP
MAP.05363_...recal.bam
HTAN Vanderbilt
HTA11_5363_2000001011
Bulk DNA
Level 2
Not Reported
Not Reported
dbGaP
MAP.06025_...recal.bam
HTAN Vanderbilt
HTA11_6025_2000001011
Bulk DNA
Level 2
Not Reported
Not Reported
dbGaP
MAP.06134_...recal.bam
HTAN Vanderbilt
HTA11_6134_2000001011
Bulk DNA
Level 2
Not Reported
Not Reported
dbGaP
MAP.06310_...recal.bam
HTAN Vanderbilt
HTA11_6310_2000001011
Bulk DNA
Level 2
Not Reported
Not Reported
dbGaP
MAP.06147_...recal.bam
HTAN Vanderbilt
HTA11_6147_2000001011
Bulk DNA
Level 2
Not Reported
Not Reported
dbGaP
MAP.01391_...recal.bam
HTAN Vanderbilt
HTA11_1391_2000001011
Bulk DNA
Level 2
Not Reported
Not Reported
dbGaP
MAP.03331_...recal.bam
HTAN Vanderbilt
HTA11_3331_2000001011
Bulk DNA
Level 2
Not Reported
Not Reported
dbGaP
MAP.02235_...recal.bam
HTAN Vanderbilt
HTA11_2235_2000001011
Bulk DNA
Level 2
Not Reported
Not Reported
dbGaP
MAP.05212_...recal.bam
HTAN Vanderbilt
HTA11_5212_2000001011
Bulk DNA
Level 2
Not Reported
Not Reported
dbGaP
MAP.05216_...recal.bam
HTAN Vanderbilt
HTA11_5216_2000001011
Bulk DNA
Level 2
Not Reported
Not Reported
dbGaP
HTAN Vanderbilt
HTA11_1938_2000001011
Bulk DNA
Level 3
Not Reported
Not Reported
Synapse
HTAN Vanderbilt
HTA11_866_2000001011
Bulk DNA
Level 3
Not Reported
Not Reported
Synapse
HTAN Vanderbilt
HTA11_347_2000001011
Bulk DNA
Level 3
Not Reported
Not Reported
Synapse
HTAN Vanderbilt
HTA11_2487_2000001011
Bulk DNA
Level 3
Not Reported
Not Reported
Synapse
HTAN Vanderbilt
HTA11_696_2000001011
Bulk DNA
Level 3
Not Reported
Not Reported
Synapse
Level
Columns (11/25)
Filename
Atlas Name
Publications
Biospecimen
Assay
Level
Organ
Diagnosis
Data Access
Metadata
View
7319-AS-4_...fastq.gz
HTAN Vanderbilt
HTA11_1938_2000001011
10X Visium
Level 1
Not Reported
Not Reported
dbGaP
7319-AS-4_...fastq.gz
HTAN Vanderbilt
HTA11_1938_2000001011
10X Visium
Level 1
Not Reported
Not Reported
dbGaP
8270-AS-00...fastq.gz
HTAN Vanderbilt
HTA11_6134_2000001011
10X Visium
Level 1
Not Reported
Not Reported
dbGaP
8270-AS-00...fastq.gz
HTAN Vanderbilt
HTA11_6134_2000001011
10X Visium
Level 1
Not Reported
Not Reported
dbGaP
7319_AS_4_...e_bam.bam
HTAN Vanderbilt
HTA11_1938_2000001011
10X Visium
Level 2
Not Reported
Not Reported
dbGaP
8270_AS_5_...e_bam.bam
HTAN Vanderbilt
HTA11_6134_2000001011
10X Visium
Level 2
Not Reported
Not Reported
dbGaP
HTAN Vanderbilt
HTA11_1938_2000001011
10X Visium
Level 4
Not Reported
Not Reported
Synapse
HTAN Vanderbilt
HTA11_6134_2000001011
10X Visium
Level 4
Not Reported
Not Reported
Synapse
HTAN Vanderbilt
HTA11_1938_2000001011
10X Visium
Auxiliary
Not Reported
Not Reported
Synapse

HTAN Vanderbilt
HTA11_6134_2000001011
10X Visium
Auxiliary
Not Reported
Not Reported
Synapse
HTAN Vanderbilt
HTA11_1938_2000001011
10X Visium
Level 3
Not Reported
Not Reported
Synapse
HTAN Vanderbilt
HTA11_1938_2000001011
10X Visium
Level 3
Not Reported
Not Reported
Synapse
HTAN Vanderbilt
HTA11_1938_2000001011
10X Visium
Level 3
Not Reported
Not Reported
Synapse
HTAN Vanderbilt
HTA11_1938_2000001011
10X Visium
Level 3
Not Reported
Not Reported
Synapse
HTAN Vanderbilt
HTA11_6134_2000001011
10X Visium
Level 3
Not Reported
Not Reported
Synapse
HTAN Vanderbilt
HTA11_6134_2000001011
10X Visium
Level 3
Not Reported
Not Reported
Synapse
HTAN Vanderbilt
HTA11_6134_2000001011
10X Visium
Level 3
Not Reported
Not Reported
Synapse
HTAN Vanderbilt
HTA11_6134_2000001011
10X Visium
Level 3
Not Reported
Not Reported
Synapse