Center for Pediatric Tumor Cell Atlas
Overview
Dr. Kai Tan is a systems biologist and Associate Professor in the Department of Pediatrics, The Children’s Hospital of Philadelphia and University of Pennsylvania. He has extensive experience studying transcriptional and epigenetic regulation in normal development and oncogenesis through a combination of experimental genomics and computational models. Dr. Tan’s laboratory has developed a number of approaches for modeling transcriptional regulatory networks, which have been used to dissect the gene regulatory networks controlling embryonic hematopoiesis, T cell differentiation, and leukemogenesis. In addition, his group has pioneered a number of popular computational algorithms for constructing models of transcriptional regulatory networks by integrating multi-dimensional genomic, epigenomic, and transcriptomic datasets. The ultimate goal of his work is to understand dynamic molecular networks, the role of combinatorial epigenetic modifications and transcriptional regulation, and the role of 3-D genomic organization in gene regulation to improve the diagnosis and treatment of cancer patients.
Principal Investigators
Kai Tan, PhD
Dr. Kai Tan is a systems biologist and Associate Professor in the Department of Pediatrics, The Children’s Hospital of Philadelphia and University of Pennsylvania. He has extensive experience studying transcriptional and epigenetic regulation in normal development and oncogenesis through a combination of experimental genomics and computational models. Dr. Tan’s laboratory has developed a number of approaches for modeling transcriptional regulatory networks, which have been used to dissect the gene regulatory networks controlling embryonic hematopoiesis, T cell differentiation, and leukemogenesis. In addition, his group has pioneered a number of popular computational algorithms for constructing models of transcriptional regulatory networks by integrating multi-dimensional genomic, epigenomic, and transcriptomic datasets. The ultimate goal of his work is to understand dynamic molecular networks, the role of combinatorial epigenetic modifications and transcriptional regulation, and the role of 3-D genomic organization in gene regulation to improve the diagnosis and treatment of cancer patients.
Steven P. Hunger, MD
Dr. Kai Tan is a systems biologist and Associate Professor in the Department of Pediatrics, The Children’s Hospital of Philadelphia and University of Pennsylvania. He has extensive experience studying transcriptional and epigenetic regulation in normal development and oncogenesis through a combination of experimental genomics and computational models. Dr. Tan’s laboratory has developed a number of approaches for modeling transcriptional regulatory networks, which have been used to dissect the gene regulatory networks controlling embryonic hematopoiesis, T cell differentiation, and leukemogenesis. In addition, his group has pioneered a number of popular computational algorithms for constructing models of transcriptional regulatory networks by integrating multi-dimensional genomic, epigenomic, and transcriptomic datasets. The ultimate goal of his work is to understand dynamic molecular networks, the role of combinatorial epigenetic modifications and transcriptional regulation, and the role of 3-D genomic organization in gene regulation to improve the diagnosis and treatment of cancer patients.