An Atlas of Pancreatic Tumorigenesis in the Context of Altered DNA Repair Occurring in High-Risk Individuals

Overview

This project focuses on creating a 3D atlas of pancreatic cancer development, particularly in individuals with genetic mutations that increase cancer risk. By mapping the progression of pre-cancerous lesions to invasive cancer, the researchers aim to uncover the molecular mechanisms behind early cancer development. The atlas will provide critical insights for early detection and intervention strategies, potentially improving outcomes for high-risk individuals.

Principal Investigators

  • Rosalie Sears, PhD, OHSU (Contact PI)
  • Jonathan Brody, PhD, OHSU
  • Elana Fertig, PhD, Johns Hopkins University
  • Laura Wood, MD, PhD, Johns Hopkins University